2rps

Solution structure of a novel insect chemokine isolated from integument

spinqualitylabelsall models 2rps Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2rps is a 1 chain structure with sequence from Mythimna separata. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B7XBA7_MYTSE Publication Abstract from PubMed Insect blood cells (hemocytes) comprise an essential arm of the immune system [1-7]. Several factors mediating recognition and phagocytosis of foreign intruders by hemocytes have been identified, but the mechanisms regulating hemocyte movement remain fragmentary. Embryonic hemocytes from Drosophila migrate along stereotypical routes in response to chemotactic signals from PVF ligands, members of the platelet-derived growth factor family [8-12]. Embryonic and larval hemocytes also accumulate at external wounds [11-13], but PVFs are not required for this response, suggesting involvement by other, unknown factors. Here we report the identification of hemocyte chemotactic peptide (HCP) from the moth Pseudaletia separata and present evidence that it stimulates aggregation and directed movement of phagocytic hemocytes. Spatiotemporal studies revealed that HCP is expressed in both epidermal cells and hemocytes, whereas structure-function studies identified post-translational modifications important for activity. HCP also shares similarities with another group of cytokines from moths called ENF peptides [14-17]. Taken together, our results identify HCP as a chemotactic cytokine that enhances clotting at wound sites in larvae. A novel peptide mediates aggregation and migration of hemocytes from an insect.,Nakatogawa S, Oda Y, Kamiya M, Kamijima T, Aizawa T, Clark KD, Demura M, Kawano K, Strand MR, Hayakawa Y Curr Biol. 2009 May 12;19(9):779-85. Epub 2009 Apr 16. PMID:19375321 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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