2rug

Refined solution structure of the first RNA recognition motif domain in CPEB3

spinqualitylabelsall models 2rug Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2rug is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CPEB3_HUMAN Publication Abstract from PubMed The family of cytoplasmic polyadenylation element binding proteins CPEB1, CPEB2, CPEB3, and CPEB4 binds to the 3'-untranslated region (3'-UTR) of mRNA, and plays significant roles in mRNA metabolism and translation regulation. They have a common domain organization, involving two consecutive RNA recognition motif (RRM) domains followed by a zinc finger domain in the C-terminal region. We solved the solution structure of the first RRM domain (RRM1) of human CPEB3, which revealed that CPEB3 RRM1 exhibits structural features distinct from those of the canonical RRM domain. Our structural data provide important information about the RNA binding ability of CPEB3 RRM1. Novel RNA recognition motif domain in the cytoplasmic polyadenylation element binding protein 3.,Tsuda K, Kuwasako K, Nagata T, Takahashi M, Kigawa T, Kobayashi N, Guntert P, Shirouzu M, Yokoyama S, Muto Y Proteins. 2014 Oct;82(10):2879-86. doi: 10.1002/prot.24651. Epub 2014 Aug 11. PMID:25066254 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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