2vai

Solution structure of a B-DNA hairpin at high pressure

spinqualitylabelsall models 2vai Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2vai is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Study of the effects of pressure on macromolecular structure improves our understanding of the forces governing structure, provides details on the relevance of cavities and packing in structure, increases our understanding of hydration and provides a basis to understand the biology of high-pressure organisms. A study of DNA, in particular, helps us to understand how pressure can affect gene activity. Here we present the first high-resolution experimental study of B-DNA structure at high pressure, using NMR data acquired at pressures up to 200 MPa (2 kbar). The structure of DNA compresses very little, but is distorted so as to widen the minor groove, and to compress hydrogen bonds, with AT pairs compressing more than GC pairs. The minor groove changes are suggested to lead to a compression of the hydration water in the minor groove. Structural change in a B-DNA helix with hydrostatic pressure.,Wilton DJ, Ghosh M, Chary KV, Akasaka K, Williamson MP Nucleic Acids Res. 2008 Jul;36(12):4032-7. Epub 2008 May 31. PMID:18515837 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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