2vvt

Glutamate Racemase (MurI) from E. faecalis in complex with a 9-Benzyl Purine inhibitor

spinqualitylabelsall models 2vvt, resolution 1.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2vvt is a 2 chain structure with sequence from Enterococcus faecalis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.65Å Ligands: DGL, I24 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MURI_ENTFA Provides the (R)-glutamate required for cell wall biosynthesis.[HAMAP-Rule:MF_00258] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained. Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.,Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. Epub 2008 Jun 24. PMID:18614367 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glutamate racemase 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA