2w1b

The structure of the efflux pump AcrB in complex with bile acid

spinqualitylabelsall models 2w1b, resolution 3.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2w1b is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.85Å Ligands: DXC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ACRB_ECOLI AcrAB is a drug efflux protein with a broad substrate specificity. Publication Abstract from PubMed Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex. The structure of the efflux pump AcrB in complex with bile acid.,Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K Mol Membr Biol. 2008 Dec;25(8):677-82. PMID:19023693 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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