2w4i

Crystal structure of Helicobacter pylori glutamate racemase in complex with D-Glutamate and an inhibitor

spinqualitylabelsall models 2w4i, resolution 1.87Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2w4i is a 4 chain structure with sequence from Helicobacter pylori. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.87Å Ligands: DGL, VGA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MURI_HELPJ Provides the (R)-glutamate required for cell wall biosynthesis (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed An SAR study of an HTS screening hit generated a series of pyridodiazepine amines as potent inhibitors of Helicobacter pylori glutamate racemase (MurI) showing highly selective anti-H. pylori activity, marked improved solubility, and reduced plasma protein binding. X-ray co-crystal E-I structures were obtained. These uncompetitive inhibitors bind at the MurI dimer interface. Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines.,Geng B, Basarab G, Comita-Prevoir J, Gowravaram M, Hill P, Kiely A, Loch J, MacPherson L, Morningstar M, Mullen G, Osimboni E, Satz A, Eyermann C, Lundqvist T Bioorg Med Chem Lett. 2009 Feb 1;19(3):930-6. Epub 2008 Dec 6. PMID:19097892 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glutamate racemase 3D structures

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