2wcn | pdb_00002wcn

Solution structure of an LNA-modified quadruplex

spinqualitylabelsall models 2wcn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2wcn is a 2 chain structure with sequence from Sterkiella nova. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: LCG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology. Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology.,Nielsen JT, Arar K, Petersen M Angew Chem Int Ed Engl. 2009;48(17):3099-103. PMID:19308940 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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