31zn

Structure of CDK11-cyclin L-SAP30BP in complex with IACS-054647

spinqualitylabelsall models 31zn, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 31zn is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.9Å Ligands: A1KC9, TPO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function S30BP_HUMAN Plays a role in transcriptional repression by promoting histone deacetylase activity, leading to deacetylation of histone H3 (PubMed:21221920). Acts as a regulator of pre-mRNA splicing by facilitating assembly of the cyclin-L-CDK11 cyclin-dependent protein kinase complex, thereby promoting phosphorylation of SF3B1 (PubMed:38059508). May be involved in the regulation of beta-2-microglobulin genes (By similarity).[UniProtKB:Q02614] (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC.

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