3ab6

Crystal structure of NAG3 bound lysozyme from Meretrix lusoria

spinqualitylabelsall models 3ab6, resolution 1.78Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ab6 is a 1 chain structure with sequence from Meretrix lusoria. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.78Å Ligands: NAG, PRD_900017 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function LYS_MERLU Has antibacterial activity (By similarity).[UniProtKB:P83673] Publication Abstract from PubMed To evaluate the structure-function relationships of invertebrate lysozymes, a new invertebrate-type (i-type) lysozyme was isolated from the common orient clam (Meretrix lusoria) and the tertiary structure of this enzyme was determined. Comparison of the tertiary structure of this enzyme with those of chicken and Venerupi philippinarum lysozymes revealed that the location of the side chain of the second catalytic residue, an aspartic acid, and the N-acetylglucosamine trimer bound at subsites A-C were different. Furthermore, the amino acid electrostatically interacting with Asp30 in V. philippinarum lysozyme, Lys108, was substituted by Gly in M. lusoria lysozyme and no other possible amino acid that could contribute to this interaction was found in M. lusoria lysozyme. It therefore seems that the substitutions of the amino acids at the interface of the V. philippinarum lysozyme dimer are likely to change the oligomeric state of the M. lusoria lysozyme. The tertiary structure of an i-type lysozyme isolated from the common orient clam (Meretrix lusoria).,Kuwano Y, Yoneda K, Kawaguchi Y, Araki T Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1202-6. doi:, 10.1107/S1744309113028170. Epub 2013 Oct 26. PMID:24192349 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Lysozyme 3D structures

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