3ara

Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors

spinqualitylabelsall models 3ara, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ara is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: MG, MKH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DUT_HUMAN This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. See Also DUTPase 3D structures

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