3avs

Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II)

spinqualitylabelsall models 3avs, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3avs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.85Å Ligands: CL, EDO, NI, OGA, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease KDM6A_HUMAN Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry. Function KDM6A_HUMAN Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. See Also Lysine-specific histone demethylase 3D structures

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