3ck6

Crystal structure of ZntB cytoplasmic domain from Vibrio parahaemolyticus RIMD 2210633

spinqualitylabelsall models 3ck6, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ck6 is a 5 chain structure with sequence from Vibpa. This structure supersedes the now removed PDB entry 3bhc. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL NonStd Res: MSE Gene: VP2389, NP_798768.1 (VIBPA) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed ZntB is the distant homolog of CorA Mg(2+) transporter within the metal ion transporter superfamily. It was early reported that the ZntB from Salmonella typhimurium facilitated efflux of Zn(2+) and Cd(2+), but not Mg(2+). Here, we report the 1.90 A crystal structure of the intracellular domain of ZntB from Vibrio parahemolyticus. The domain forms a funnel-shaped homopentamer that is similar to the full-length CorA from Thermatoga maritima, but differs from two previously reported dimeric structures of truncated CorA intracellular domains. However, no Zn(2+) or Cd(2+) binding sites were identified in the high-resolution structure. Instead, 25 well-defined Cl(-) ions were observed and some of these binding sites are highly conserved within the ZntB family. Continuum electrostatics calculations suggest that the central pore of the funnel is highly attractive for cations, especially divalents. The presence of the bound Cl(-) ions increases the stability of cations along the pore suggesting they could be important in enhancing cation transport. Structure and electrostatic property of cytoplasmic domain of ZntB transporter.,Tan K, Sather A, Robertson JL, Moy S, Roux B, Joachimiak A Protein Sci. 2009 Oct;18(10):2043-52. PMID:19653298 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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