3e6y

Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A

spinqualitylabelsall models 3e6y, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3e6y is a 4 chain structure with sequence from Nicotiana plumbaginifolia and Nicotiana tabacum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.5Å Ligands: CL, CW1, TPO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function 1433C_TOBAC Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Cotylenin A, a fungal metabolite originally described as a cytokinin-like bioactive substance against plants shows differentiation-inducing and anti-tumor activity in certain human cancers. Here, we present the crystal structure of cotylenin A acting on a 14-3-3 regulatory protein complex. By comparison with the closely related, but non-anticancer agent fusicoccin A, a rationale for the activity of cotylenin A in human cancers is presented. This class of fusicoccane diterpenoids are possible general modulators of 14-3-3 protein-protein interactions. In this regard, specificities for individual 14-3-3/target protein complexes might be achieved by varying the substituent pattern of the diterpene ring system. As the different activities of fusicoccin A and cotylenin A in human cancers suggest, hydroxylation of C12 might be a sufficient determinant of structural specificity. A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A.,Ottmann C, Weyand M, Sassa T, Inoue T, Kato N, Wittinghofer A, Oecking C J Mol Biol. 2009 Mar 6;386(4):913-9. PMID:19244612 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also 14-3-3 protein 3D structures

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