3g61

Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

spinqualitylabelsall models 3g61, resolution 4.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3g61 is a 2 chain structure with sequence from Mus musculus. The March 2010 RCSB PDB Molecule of the Month feature on P-glycoprotein by David Goodsell is 10.2210/rcsb_pdb/mom_2010_3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 4.35Å Ligands: 2J8 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MDR1A_MOUSE Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

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