3ia4

Moritella profunda dihydrofolate reductase (DHFR) in complex with NADPH and methotrexate (MTX)

spinqualitylabelsall models 3ia4, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ia4 is a 4 chain structure with sequence from Moritella profunda. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: MTX, NDP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q70YQ6_MORPR Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Dihydrofolate reductase 3D structures

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