3isq

Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase

spinqualitylabelsall models 3isq, resolution 1.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3isq is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.75Å Ligands: CL, CO, EDO, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease HPPD_HUMAN Defects in HPD are the cause of tyrosinemia type 3 (TYRO3) [MIM:276710. TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK) [MIM:140350. HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Function HPPD_HUMAN Key enzyme in the degradation of tyrosine. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Dioxygenase 3D structures

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