3j1t

High affinity dynein microtubule binding domain - tubulin complex

Loading... Status: waiting for Mol* initialization Structural highlights 3j1t is a 3 chain structure with sequence from Bos taurus and Mus musculus. The August 2014 RCSB PDB Molecule of the Month feature on Dynein by David Goodsell is 10.2210/rcsb_pdb/mom_2014_8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 9.7Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease DYHC1_MOUSE Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. Function DYHC1_MOUSE Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. See Also Dynein 3D structures Tubulin 3D Structures

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