3jxt | pdb_00003jxt

Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand

spinqualitylabelsall models 3jxt, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3jxt is a 4 chain structure with sequence from Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: 4DB, ACE, ACT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DLG3_RAT Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells. Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions.,Sainlos M, Iskenderian-Epps WS, Olivier NB, Choquet D, Imperiali B J Am Chem Soc. 2013 Mar 27;135(12):4580-3. doi: 10.1021/ja309870q. Epub 2013 Mar , 13. PMID:23480637 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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