3l0u

The crystal structure of unmodified tRNAPhe from Escherichia coli

spinqualitylabelsall models 3l0u, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3l0u is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: K, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Post-transcriptional nucleoside modifications fine-tune the biophysical and biochemical properties of transfer RNA (tRNA) so that it is optimized for participation in cellular processes. Here we report the crystal structure of unmodified tRNA(Phe) from Escherichia coli at a resolution of 3 A. We show that in the absence of modifications the overall fold of the tRNA is essentially the same as that of mature tRNA. However, there are a number of significant structural differences, such as rearrangements in a triplet base pair and a widened angle between the acceptor and anticodon stems. Contrary to previous observations, the anticodon adopts the same conformation as seen in mature tRNA. The crystal structure of unmodified tRNAPhe from Escherichia coli.,Byrne RT, Konevega AL, Rodnina MV, Antson AA Nucleic Acids Res. 2010 Jul 1;38(12):4154-62. Epub 2010 Mar 4. PMID:20203084 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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