3nth

Crystal structure of Tudor and Aubergine [R13(me2s)] complex

spinqualitylabelsall models 3nth, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3nth is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.8Å Ligands: 2MR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TUD_DROME Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Piwi proteins are modified by symmetric dimethylation of arginine (sDMA), and the methylarginine-dependent interaction with Tudor domain proteins is critical for their functions in germline development. Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage. Furthermore, the unexpected Tudor-SN/p100 fold of eTud is important for sensing the position of sDMA. The structural information provides mechanistic insights into sDMA-dependent Piwi-Tudor interaction, and the recognition of sDMA by Tudor domains in general. Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.,Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, Xu RM Genes Dev. 2010 Sep 1;24(17):1876-81. Epub 2010 Aug 16. PMID:20713507 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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