3o31

E81Q mutant of MtNAS in complex with a reaction intermediate

spinqualitylabelsall models 3o31, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3o31 is a 2 chain structure with sequence from Methanothermobacter thermautotrophicus str. Delta H. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: 3O3, BR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function O26771_METTH Publication Abstract from PubMed We determined the three-dimensional structure of a complex between an archaeal nicotianamine synthase homologue and a chemically synthesised reaction intermediate. This structure suggests that the enzymes cavity allows both an ordered substrate binding and provides energetic coupling of the reaction intermediate formation and translocation. The crystallographic structure of thermoNicotianamine synthase with a synthetic reaction intermediate highlights the sequential processing mechanism.,Dreyfus C, Larrouy M, Cavelier F, Martinez J, Pignol D, Arnoux P Chem Commun (Camb). 2011 May 28;47(20):5825-7. Epub 2011 Apr 12. PMID:21487608 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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