3omz

Crystal structure of MICA-specific human gamma delta T cell receptor

spinqualitylabelsall models 3omz, resolution 3.04Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3omz is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.04Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed gammadelta T cells play important roles in bridging innate and adaptive immunity, but their recognition mechanisms remain poorly understood. Human gammadelta T cells of the V(delta)1 subset predominate in intestinal epithelia and respond to MICA and MICB (MHC class I chain-related, A and B; MIC) self-antigens, mediating responses to tumorigenesis or viral infection. The crystal structure of an MIC-reactive V(delta)1 gammadelta T-cell receptor (TCR) showed expected overall structural homology to antibodies, alphabeta, and other gammadelta TCRs, but complementary determining region conformations and conservation of V(delta)1 use revealed an uncharacteristically flat potential binding surface. MIC, likewise, serves as a ligand for the activating immunoreceptor natural killer group 2, D (NKG2D), also expressed on gammadelta T cells. Although MIC recognition drives both the TCR-dependent stimulatory and NKG2D-dependent costimulatory signals necessary for activation, interaction analyses showed that MIC binding by the two receptors was mutually exclusive. Analysis of relative binding kinetics suggested sequential recognition, defining constraints for the temporal organization of gammadelta T-cell/target cell interfaces. Crystal structure of a {gamma}{delta} T-cell receptor specific for the human MHC class I homolog MICA.,Xu B, Pizarro JC, Holmes MA, McBeth C, Groh V, Spies T, Strong RK Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2414-9. Epub 2011 Jan 24. PMID:21262824 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also T-cell receptor 3D structures

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