3p13

Complex Structure of D-ribose Pyranase Sa240 with D-ribose

spinqualitylabelsall models 3p13, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3p13 is a 4 chain structure with sequence from Staphylococcus aureus subsp. aureus NCTC 8325. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.35Å Ligands: RIP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RBSD_STAA8 Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.[HAMAP-Rule:MF_01661] Publication Abstract from PubMed Ribose is transported into cells in its pyranose form and must be rearranged to its furanose form for further utilization. Ribose pyranase RbsD catalyzes the conversion of ribose from the pyranose to furanose form. This is the key step for substrate supply to ribokinase RbsK, which converts ribose to ribose-5-phosphate for further metabolism. Sequence analysis indicated Sa240 from Staphylococcus aureus was a ribose pyranase homolog. Here we showed that Sa240 formed dimeric structure both in solution and in crystal. S240-ribose complex structure showed a ribose binding site formed by an incomplete active site compared with RbsD. Because the catalytic activity of ribose pyranase depends on its oligomeric state, we propose Sa240 is catalytically inactive in its dimeric structure. Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus.,Wang L, Wu M, Zang J J Struct Biol. 2011 May;174(2):413-9. Epub 2011 Jan 27. PMID:21276853 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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