3q4t

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin

spinqualitylabelsall models 3q4t, resolution 1.96Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3q4t is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.96Å Ligands: EDO, PG4, SO4, TAK Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function AVR2A_HUMAN On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

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