3q90
From Proteopedia
Jump to navigationJump to search
Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1
| ||||||||||||
Structural highlights
FunctionG3BP1_HUMAN May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.[1] [2] References
| ||||||||||||||||||
This page was last modified 11:37, 14 March 2024.