3sm1

The crystal structure of XMRV protease complexed with pepstatin A

spinqualitylabelsall models 3sm1, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3sm1 is a 4 chain structure with sequence from DG-75 Murine leukemia virus and Streptomyces argenteolus subsp. toyonakensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: FMT, IVA, STA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9E7M1_9GAMR Publication Abstract from PubMed Interactions between the protease (PR) encoded by the xenotropic murine leukemia virus-related virus and a number of potential inhibitors have been investigated by biochemical and structural techniques. It was observed that several inhibitors used clinically against HIV PR exhibit nanomolar or even subnanomolar values of K(i) , depending on the exact experimental conditions. Both TL-3, a universal inhibitor of retroviral PRs, and some inhibitors originally shown to inhibit plasmepsins were also quite potent, whereas inhibition by pepstatin A was considerably weaker. Crystal structures of the complexes of xenotropic murine leukemia virus-related virus PR with TL-3, amprenavir and pepstatin A were solved at high resolution and compared with the structures of complexes of these inhibitors with other retropepsins. Whereas TL-3 and amprenavir bound in a predictable manner, spanning the substrate-binding site of the enzyme, two molecules of pepstatin A bound simultaneously in an unprecedented manner, leaving the catalytic water molecule in place. Structured digital abstract * XMRVPR and XMRVPR bind by x-ray crystallography (View interaction). Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.,Li M, Gustchina A, Matuz K, Tozser J, Namwong S, Goldfarb NE, Dunn BM, Wlodawer A FEBS J. 2011 Sep 23. doi: 10.1111/j.1742-4658.2011.08364.x. PMID:21951660 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus protease 3D structures

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