3sto

Serpin from the trematode Schistosoma Haematobium

spinqualitylabelsall models 3sto, resolution 2.41Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3sto is a 1 chain structure with sequence from Schistosoma haematobium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.41Å Ligands: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q26502_SCHHA Publication Abstract from PubMed Parasitic organisms are constantly challenged by the defence mechanisms of their respective hosts, which often depend on serine protease activities. Consequently, protease inhibitors such as those belonging to the serpin superfamily have emerged as protective elements that support the survival of the parasites. This report describes the crystal structure of ShSPI, a serpin from the trematode Schistosoma haematobium. The protein is exposed on the surface of invading cercaria as well as of adult worms, suggesting its involvement in the parasite-host interaction. While generally conforming to the well established serpin fold, the structure reveals several distinctive features, mostly concerning the helical subdomain of the protein. It is proposed that these peculiarities are related to the unique biological properties of a small serpin subfamily which is conserved among pathogenic schistosomes. Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.,Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergraber OH Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):686-94. doi:, 10.1107/S0907444912008372. Epub 2012 May 17. PMID:22683791 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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