3sum | pdb_00003sum

Crystal structure of cerato-platanin 5 from M. perniciosa (MpCP5)

spinqualitylabelsall models 3sum, resolution 1.87Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3sum is a 4 chain structure with sequence from Moniliophthora perniciosa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.87Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B2C3I4_MONPR Publication Abstract from PubMed Cerato-platanins (CP) are small, cysteine-rich fungal-secreted proteins involved in the various stages of the host-fungus interaction process, acting as phytotoxins, elicitors, and allergens. We identified 12 CP genes (MpCP1 to MpCP12) in the genome of Moniliophthora perniciosa, the causal agent of witches' broom disease in cacao, and showed that they present distinct expression profiles throughout fungal development and infection. We determined the X-ray crystal structures of MpCP1, MpCP2, MpCP3, and MpCP5, representative of different branches of a phylogenetic tree and expressed at different stages of the disease. Structure-based biochemistry, in combination with nuclear magnetic resonance and mass spectrometry, allowed us to define specialized capabilities regarding self-assembling and the direct binding to chitin and N-acetylglucosamine (NAG) tetramers, a fungal cell wall building block, and to map a previously unknown binding region in MpCP5. Moreover, fibers of MpCP2 were shown to act as expansin and facilitate basidiospore germination whereas soluble MpCP5 blocked NAG6-induced defense response. The correlation between these roles, the fungus life cycle, and its tug-of-war interaction with cacao plants is discussed. Functional diversification of cerato-platanins in Moniliophthora perniciosa as seen by differential expression and protein function specialization.,de O Barsottini MR, de Oliveira JF, Adamoski D, Teixeira PJ, do Prado PF, Tiezzi HO, Sforca ML, Cassago A, Portugal RV, de Oliveira PS, de M Zeri AC, Dias SM, Pereira GA, Ambrosio AL Mol Plant Microbe Interact. 2013 Nov;26(11):1281-93. doi: , 10.1094/MPMI-05-13-0148-R. PMID:23902259 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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