3t7v

Crystal structure of methylornithine synthase (PylB)

spinqualitylabelsall models 3t7v, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3t7v is a 1 chain structure with sequence from Methanosarcina barkeri str. Fusaro. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: MD0, SAM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PYLB_METBF Catalyzes the isomerization of L-lysine to (2R,3R)-3-methylornithine via a radical-based mechanism, a step in the biosynthesis pathway of pyrrolysine. Publication Abstract from PubMed Made by the barrel load: The biosynthetic pathway of the recently discovered 22nd amino acid, pyrrolysine, starts with an isomerization of lysine to methylornithine, catalyzed by PylB. The X-ray crystal structure of PylB is determined and shows it has a TIM barrel fold. The sealed central cavity contains a [4Fe-4S] cluster, S-adenosylmethionine (SAM), and methylornithine, whose 2R,3R configuration could be confirmed. The data suggest a fragmentation-recombination mechanism via a glycyl radical intermediate. Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis.,Quitterer F, List A, Eisenreich W, Bacher A, Groll M Angew Chem Int Ed Engl. 2011 Nov 16. doi: 10.1002/anie.201106765. PMID:22095926 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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