3u3r
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Crystal structure of D249G mutated Human SULT1A1 bound to PAP and P-NITROPHENOL
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Structural highlights
FunctionST1A1_HUMAN Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.[1] [2] See AlsoReferences
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This page was last modified 10:16, 1 March 2024.