3vkc

Crystal structure of MoeO5 soaked with pyrophosphate

spinqualitylabelsall models 3vkc, resolution 1.66Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3vkc is a 2 chain structure with sequence from Streptomyces viridosporus ATCC 14672. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.66Å Ligands: FPQ, MG, POP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A011_STRVD Publication Abstract from PubMed New antibiotics are needed because of the increasing occurrence of multidrug resistance, as seen in Staphylococcus aureus (MRSA). The initiating step of the biosynthesis of the next-generation drug moenomycin is catalyzed by MoeO5, which is a prenyltransferase with triose-phosphate-isomerase barrel structure as was shown by E. Oldfield, R.-T. Guo, and co-workers in their Communication (DOI:10.1002/anie.201108002). The transferred farnesyl group undergoes a trans-to-cis conversion in its first double bond. Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes.,Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, Guo RT Angew Chem Int Ed Engl. 2012 Mar 20. doi: 10.1002/anie.201201339. PMID:022434765 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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