3wah

Crystal Structure of HasAp with Iron MesoporphyrinIX

spinqualitylabelsall models 3wah, resolution 1.54Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3wah is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.54Å Ligands: MH0 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G3XD33_PSEAE Publication Abstract from PubMed The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasAp ) can capture several synthetic metal complexes other than heme. The crystal structures of HasAp harboring synthetic metal complexes revealed only small perturbation of the overall HasAp structure. An inhibitory effect upon heme acquisition by HasAp bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasAp bound to iron-phthalocyanine inhibits heme acquisition in the presence of heme-bound HasAp as an iron source. Inhibition of Heme Uptake in Pseudomonas aeruginosa by its Hemophore (HasAp ) Bound to Synthetic Metal Complexes.,Shirataki C, Shoji O, Terada M, Ozaki S, Sugimoto H, Shiro Y, Watanabe Y Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2862-6. doi: 10.1002/anie.201307889., Epub 2014 Feb 7. PMID:24604808 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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