3zdw

Substrate and dioxygen binding to the endospore coat laccase CotA from Bacillus subtilis

spinqualitylabelsall models 3zdw, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3zdw is a 1 chain structure with sequence from Bacillus subtilis. This structure supersedes the now removed PDB entry 1uvw. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.4Å Ligands: CU1, EBS, GOL, OXY Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function COTA_BACSU Involved in brown pigmentation during sporogenesis. Publication Abstract from PubMed The CotA laccase from the endospore coat of Bacillus subtilis has been crystallized in the presence of the non-catalytic co-oxidant 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), and the structure was determined using synchrotron radiation. The binding site for this adduct is well defined and indicates how ABTS, in conjunction with laccases, could act as an oxidative mediator toward non-phenolic moieties. In addition, a dioxygen moiety is clearly defined within the solvent channel oriented toward one of the T3 copper atoms in the trinuclear center. Substrate and dioxygen binding to the endospore coat laccase from Bacillus subtilis.,Enguita FJ, Marcal D, Martins LO, Grenha R, Henriques AO, Lindley PF, Carrondo MA J Biol Chem. 2004 May 28;279(22):23472-6. Epub 2004 Feb 4. PMID:14764581 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Laccase 3D structures

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