4ano | pdb_00004ano

Crystal Structure Geobacillus thermodenitrificans EssB cytoplasmic fragment

spinqualitylabelsall models 4ano, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ano is a 1 chain structure with sequence from Geobacillus thermodenitrificans NG80-2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: CL, MSE, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The membrane-bound EssB is an integral and essential component of the bacterial type VII secretion system that can contribute to pathogenicity. The architecture of Geobacillus thermodenitrificans EssB has been investigated by combining crystallographic and EPR spectroscopic methods. The protein forms a dimer that straddles the cytoplasmic membrane. A helical fold is observed for the C-terminal segment, which is positioned on the exterior of the membrane. This segment contributes most to dimer formation. The N-terminal segment displays a structure related to the pseudokinase fold and may contribute to function by recognizing substrates or secretion system partners. The remaining part of EssB may serve as an anchor point for the secretion apparatus, which is embedded in the cytoplasmic membrane with the C-terminal domain protruding out to interact with partner proteins or components of peptidoglycan. The architecture of EssB, an integral membrane component of the type VII secretion system.,Zoltner M, Norman DG, Fyfe PK, El Mkami H, Palmer T, Hunter WN Structure. 2013 Apr 2;21(4):595-603. doi: 10.1016/j.str.2013.02.007. Epub 2013, Mar 14. PMID:23499020 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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