4b2v

S64, a spider venom toxin peptide from Sicarius dolichocephalus

spinqualitylabelsall models 4b2v, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4b2v is a 1 chain structure with sequence from Sicarius dolichocephalus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4b2u Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We present solution-state NMR structures for two putative venom peptides from Sicarius dolichocephalus. These peptides were identified from cDNA libraries created from venom gland mRNA and then recombinantly expressed. They are the first structures from any species of Sicarius spiders, and the first peptide structures for any haplogyne spiders. These peptides are homologous to one another, and while they have at most only 20% sequence identity with known venom peptides their structures follow the inhibitor cystine knot motif that has been found in a broad range of venom peptides. Solution Structures of Two Homologous Venom Peptides from Sicarius dolichocephalus.,Loening NM, Wilson ZN, Zobel-Thropp PA, Binford GJ PLoS One. 2013;8(1):e54401. doi: 10.1371/journal.pone.0054401. Epub 2013 Jan 14. PMID:23342149 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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