4b4d

Crystal structure of FAD-containing ferredoxin-NADP reductase from Xanthomonas axonopodis pv. citri

spinqualitylabelsall models 4b4d, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4b4d is a 1 chain structure with sequence from Xanthomonas citri pv. citri str. 306. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: CL, FAD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q8PMH0_XANAC Publication Abstract from PubMed We have solved the structure of ferredoxin-NADP(H) reductase, FPR, from the plant pathogen Xanthomonas axonopodis pv. citri, responsible for citrus canker, at a resolution of 1.5 A. This structure reveals differences in the mobility of specific loops when compared to other FPRs, probably unrelated to the hydride transfer process, which contributes to explaining the structural and functional divergence between the subclass I FPRs. Interactions of the C-terminus of the enzyme with the phosphoadenosine of the cofactor FAD limit its mobility, thus affecting the entrance of nicotinamide into the active site. This structure opens the possibility of rationally designing drugs against the X. axonopodis pv. citri phytopathogen. Crystal Structure of the FAD-Containing Ferredoxin-NADP (+) Reductase from the Plant Pathogen Xanthomonas axonopodis pv. citri.,Tondo ML, Hurtado-Guerrero R, Ceccarelli EA, Medina M, Orellano EG, Martinez-Julvez M Biomed Res Int. 2013;2013:906572. doi: 10.1155/2013/906572. Epub 2013 Aug 1. PMID:23984418 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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