4cpc

Crystal structure of human synaptonemal complex protein SYCP3

spinqualitylabelsall models 4cpc, resolution 2.24Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4cpc is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.24Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease SYCP3_HUMAN Male infertility with normal virilization due to meiosis defect. The disease is caused by mutations affecting the gene represented in this entry. Function SYCP3_HUMAN Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

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