4d6v

Crystal structure of signal transducing protein

spinqualitylabelsall models 4d6v, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4d6v is a 1 chain structure with sequence from Cryptococcus neoformans var. grubii H99. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function J9W3X8_CRYNH Publication Abstract from PubMed The atypical Gbeta-like/RACK1 Gib2 protein promotes cAMP signalling that plays a central role in regulating the virulence of Cryptococcus neoformans. Gib2 contains a seven-bladed beta transducin structure and is emerging as a scaffold protein interconnecting signalling pathways through interactions with various protein partners. Here, we present the crystal structure of Gib2 at a 2.2-A resolution. The structure allows us to analyse the association between Gib2 and the ribosome, as well as to identify the Gib2 amino acid residues involved in ribosome binding. Our studies not only suggest that Gib2 has a role in protein translation but also present Gib2 as a physical link at the crossroads of various regulatory pathways important for the growth and virulence of C. neoformans. Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in Cryptococcus neoformans.,Ero R, Dimitrova VT, Chen Y, Bu W, Feng S, Liu T, Wang P, Xue C, Tan SM, Gao YG Sci Rep. 2015 Mar 3;5:8688. doi: 10.1038/srep08688. PMID:25732347 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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