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The crystal structure of DNA starvation/stationary phase protection protein Dps from Yersinia pestis KIM 10
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Structural highlights
FunctionDPS_YERPE During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.[HAMAP-Rule:MF_01441] See AlsoContents | ||||||||||||||||||||
This page was last modified 14:47, 14 March 2024.