4gqj

Complex of a binuclear Ruthenium compound D,D-([mu-(11,11')-bi(dppz)-(1,10-phenanthroline)4-Ru2]4+) bound to d(CGTACG)

spinqualitylabelsall models 4gqj, resolution 2.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4gqj is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.951Å Ligands: RR2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The crystal structure of the Delta,Delta enantiomer of the binuclear "light-switch" ruthenium complex [mu-(11,11'-bidppz)(1,10-phenanthroline)4 Ru2 ](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves. Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of AT base pairs and cross-linking of DNA duplexes.,Boer DR, Wu L, Lincoln P, Coll M Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1949-52. doi: 10.1002/anie.201308070., Epub 2014 Jan 21. PMID:24449275 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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