4gu4

Crystal structure of the T1L reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose

spinqualitylabelsall models 4gu4, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4gu4 is a 3 chain structure with sequence from Mammalian orthoreovirus 1 Lang. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.5Å Ligands: BGC, GAL, SIA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SIGM1_REOVL Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). See Also Virus coat proteins 3D structures

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