4hg9

Crystal structure of AhV_bPA, a basic PLA2 from Agkistrodon halys pallas venom

spinqualitylabelsall models 4hg9, resolution 1.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4hg9 is a 4 chain structure with sequence from Gloydius halys. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.6Å Ligands: CA, CIT, G3P, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PA2BB_GLOHA Snake venom phospholipase A2 (PLA2) that shows potent hemolytic activity, and exhibits medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 90 nM). It is one of the few phospholipases A2 capable of hydrolyzing the phospholipids of E.coli membranes in the presence of a bactericidal/permeability-increasing protein (BPI) of neutrophils. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. See Also Phospholipase A2 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA