4hkr

Calcium release-activated calcium (CRAC) channel ORAI

spinqualitylabelsall models 4hkr, resolution 3.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4hkr is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.3511Å Ligands: BA, FE, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CRCM1_DROME Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import. Publication Abstract from PubMed The plasma membrane protein Orai forms the pore of the calcium release-activated calcium (CRAC) channel and generates sustained cytosolic calcium signals when triggered by depletion of calcium from the endoplasmic reticulum. The crystal structure of Orai from Drosophila melanogaster, determined at 3.35 angstrom resolution, reveals that the calcium channel is composed of a hexameric assembly of Orai subunits arranged around a central ion pore. The pore traverses the membrane and extends into the cytosol. A ring of glutamate residues on its extracellular side forms the selectivity filter. A basic region near the intracellular side can bind anions that may stabilize the closed state. The architecture of the channel differs markedly from other ion channels and gives insight into the principles of selective calcium permeation and gating. Crystal structure of the calcium release-activated calcium channel Orai.,Hou X, Pedi L, Diver MM, Long SB Science. 2012 Dec 7;338(6112):1308-13. doi: 10.1126/science.1228757. Epub 2012, Nov 22. PMID:23180775 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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