4iim

Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide

spinqualitylabelsall models 4iim, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4iim is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Ligands: UNX Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ITSN1_HUMAN Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. See Also Intersectin

Proteopedia Page Contributors and Editors (what is this?)

OCA