4iwy

SeMet-substituted RimK structure

spinqualitylabelsall models 4iwy, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4iwy is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.9Å Ligands: ADP, GLU, MSE, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RIMK_ECOLI Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6. Publication Abstract from PubMed We report herein the crystal structure of E. coli RimK at 2.85 A resolution, an enzyme that catalyzes the post-translational addition of up to fifteen C-terminal glutamate residues to ribosomal protein S6. The structure belongs to the ATP-grasp superfamily and is organized as a tetramer, consistent with gel filtration analysis. Each subunit consists of three distinct structural domains and the active site is located in the cleft between these domains. The catalytic reaction appears to occur at the junction between the three domains since ATP binds between the B and C domains, and other substrates bind nearby. (c) Proteins 2013;. (c) 2013 Wiley Periodicals, Inc. Structure and function of Escherichia coli RimK, an ATP-grasp fold, L-glutamyl ligase enzyme.,Zhao G, Jin Z, Wang Y, Allewell NM, Tuchman M, Shi D Proteins. 2013 Apr 23. doi: 10.1002/prot.24311. PMID:23609986 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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