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Crystal structure of the human telomeric Stn1-Ten1 complex
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Structural highlights
FunctionSTN1_HUMAN Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.[1] [2] References
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This page was last modified 12:05, 1 March 2024.