4kq6

Product complex of lumazine synthase from candida glabrata

spinqualitylabelsall models 4kq6, resolution 2.24Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4kq6 is a 10 chain structure with sequence from Candida glabrata CBS 138. This structure supersedes the now removed PDB entry 4gef. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.24Å Ligands: DLZ, GOL, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q6FXA8_CANGA Publication Abstract from PubMed Candida glabrata has emerged as an important fungal pathogen with intrinsic resistance to azole drugs. The limited efficacy of and resistance to existing antifungals is driving the need to identify new drug targets. The enzyme 6,7-dimethyl-8-(D-ribityl)lumazine synthase is part of the riboflavin-biosynthesis pathway essential to fungi and bacteria and is a potential drug target for the development of broad-spectrum antifungal drugs. The X-ray crystal structure of recombinant lumazine synthase from C. glabrata was obtained at 2.24 A resolution and revealed a dimer of homopentamers, with one in five subunits containing a product molecule from the catalytic reaction. Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.,Shankar M, Wilbanks SM, Nakatani Y, Monk BC, Tyndall JD Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1580-6. doi:, 10.1107/S0907444913010949. Epub 2013 Jul 20. PMID:23897480 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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