Structural highlights
4lt5 is a 3 chain structure with sequence from Naegleria gruberi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.893Å |
| Ligands: | 5CM, EDO, MN, OGA, SO4 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
TET1_NAEGR Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), and thereby plays a role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).[1] [2]
References
- ↑ Hashimoto H, Pais JE, Zhang X, Saleh L, Fu ZQ, Dai N, Correa IR, Zheng Y, Cheng X. Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. Nature. 2013 Dec 25. doi: 10.1038/nature12905. PMID:24390346 doi:https://dx.doi.org/10.1038/nature12905
- ↑ Hashimoto H, Pais JE, Dai N, Correa IR Jr, Zhang X, Zheng Y, Cheng X. Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Res. 2015 Aug 31. pii: gkv870. PMID:26323320 doi:https://dx.doi.org/10.1093/nar/gkv870
