4m61

Crystal structure of unliganded anti-DNA Fab A52

spinqualitylabelsall models 4m61, resolution 1.62Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4m61 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.62Å Ligands: SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed A52 is a murine monoclonal antibody isolated from autoimmune New Zealand Black/New Zealand White F1 mice that recognizes single and double stranded DNA. This mouse strain spontaneously develops systemic lupus erythematosus-like symptoms and has served as a model for that disease for many years. The 1.62 A crystal structure of the A52 Fab fragment reveals an H3 complementarity determining region with four closely spaced arginine residues, creating a positively charged surface to accommodate bound DNA. Proteins 2014. (c) 2014 Wiley Periodicals, Inc. Crystal structure determination of anti-DNA Fab A52.,Stanfield RL, Eilat D Proteins. 2014 Jan 22. doi: 10.1002/prot.24514. PMID:24449198 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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