4m6w

Crystal structure of the C-terminal segment of FANCM in complex with FAAP24

spinqualitylabelsall models 4m6w, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4m6w is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.9Å Ligands: SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease FANCM_HUMAN Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry. Function FANCM_HUMAN ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. [REFERENCE:7][REFERENCE:8]

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